Peptide Synthesizers
P11 Automated Peptide Synthesizer
The P11 Peptide Synthesizer is an easy to use and affordable instrument for synthesis of very high quality peptides.
Description
The P11 is the only synthesizer available with both automated reactor heating and UV monitoring. These valuable synthesis tools allow chemists to synthesize longer and more difficult peptides and to gain more synthesis information about those peptides. For example the antimicrobial peptide Gomesin has been successfully synthesized using conventional heating.
Key Features
- High quality peptides
- Any scale from 0.005 to 5.0 mmol
- Easy to use; define own protocols or use the peptide wizard software
- Performs any Fmoc or t-Boc chemistries
- PNA synthesis
- Safe to use, instrument is totally enclosed
- Fully automatic with no limit to number of amino acids
- Disposable reactors and amino acid containers
- Uses commercially available resins and reagents
- Self diagnostics with fluidic sensors checking reagent delivery, emptying and transfers
High Quality Peptide
- Inert atmosphere throughout
- Precise and fast reagent delivery and washing
- Efficient inversion mixing
- Bottom filtration from disposable reactors
- Fresh amino acids in powder
- Pre-activation vessel
- Multi-tasking
- Heated reactors
- UV monitoring
Chemistry
- Fmoc or t-Boc
- PNA synthesis
- In situ or preactivation
- Use any coupling reagents; HBTU, HCTU, HATU, TBTU, PyBOP, DIC etc
- Use any resins; polystyrene or PEG based supports
- Use any protocols
- Synthesize any length of peptides
Ease of Use
- Very easy to use software; import the sequence, fill in quantity and resin specifications then press run
- Software generated worksheet tells the user what to prepare
- Free choice of chemistry, present and future
- Disposable reactors and amino acid containers
- 60 amino acid containers, no limit to how many can be added
- Enclosed cabinet for safe bench top use
- Easy cleave system direct from the disposable reactor
- Logfile of each synthesis
- Easy cleavage on the machine or transfer disposable reactor to the P12 Cleavage Device
Dimensions
W – 84cm or 33in D – 59cm or 23in H – 70cm or 28in
Instrument Specification
| Scale | 0.005 to 5.0 mmol | |
| Chemistry | Fmoc or t-Boc Dissolve dry amino acids or use pre dissolved |
|
| Activation method | Pre-activation or in situ, user selectable. HBTU, HCTU, COMU, DIC, PyBop etc | |
| Amino acid vessels | 60 of 15 mL or 30 of 50 mL arranged in a carousel so no limit | |
| Reaction vessel sizes | 10 mL, 40 mL and 125 mL | |
| Reagent/solvent bottles | 9, range from 250 mL to 19 litres 2 of 10 litres each |
|
| Mixing system | Over centre mixing with variable speed and amplitude | |
| Inert atmosphere | 100% throughout the system | |
| Fluid measurement | Fill loops for calibration free measurement of reagents Timed delivery for washing solvents |
|
| Power | Variable range from 240V/50 Hz to 100V/ 60 Hz | |
| Safety | CE marked, system enclosed with door interlock | |
| Ventilation | Designed for bench top use with extractor attached | |
| Logfile | Printable logfile for each synthesis run | |
| Software | User friendly interface, pre-written protocols or user defines own | |
| Controller | Desktop PC | |
| Temperature | Ambient to +90 ºC | |
| Dimensions | Width 84 cm (33″), depth 60 cm (23″), height 70 cm (28″) |
P12 Cleavage Device
Key Features
- No need to transfer resin around
- Inert atmosphere
- Variable over centre mixing
- Small footprint to fit into any fume cupboard
P14 Peptide Synthesizer
P14 Peptide Synthesizer is an economical semi-automated instrument for the synthesis of very high quality peptides. This is the smallest and lowest cost peptide synthesizer available.
Key Features
- High quality peptides
- Any scale from 0.05 to 5.0 mmoles
- Easy to use; use existing or define your own protocols
- Automates the resin washing and deprotection steps of synthesis
- Performs any Fmoc or t-Boc chemistries
- Heated reactors
- PNA synthesis
- Safe to use, instrument is totally enclosed
- Disposable reactors
- Uses commercially available resins and reagents
- Optional reactor heating
High Quality Peptide
- Inert atmosphere throughout
- Precise and fast reagent delivery and washing
- Efficient inversion mixing & nitrogen bubbling
- Bottom filtration from disposable reactors
Ease of Use
- Very easy to use touch screen display
- Enter the sequence, fill in quantity and resin and press run
- Software generated worksheet tells the user what to prepare
- Free choice of chemistry, present and future
- Disposable reactors
- Logfile of each synthesis
- Easy cleave system direct from the disposable reactor
Chemistry
- Fmoc or t-Boc
- In situ or pre-activation
- Coupling reagents HBTU, HCTU, HATU, TBTU, PyBOP, DIC etc
- PNA synthesis
- Use any resins; polystyrene or PEG
- Use any protocols
- Synthesize any length of peptides
Instrument Specification
| Scale | 0.05 – 5.0 mmoles | |
| Chemistry | Fmoc or t-Boc | |
| Activation method | Pre-activation or in-situ, user selectable. HBTU, HCTU, DIC, PyBOP, etc | |
| Reaction vessel sizes | 10 mL, 40 mL, 125 mL | |
| Reagent/solvent bottles | 3, range from 250 mL to 19 litres | |
| Reactor heating | ambient to + 80 degrees C | |
| Mixing system | Over centre mixing with variable speed and amplitude | |
| Inert atmosphere | 100% throughout the system | |
| Fluid measurement | Timed delivery | |
| Power | Variable range from 240V/50Hz or 100V/60Hz | |
| Logfile | Printable logfile for each synthesis run | |
| Dimensions | Width 33 cm (13”), depth 27 cm (11”), height 33 cm (13”) + solvent storage unit |
Activo-PLS Parallel Peptide Synthesizer
Description
The PLS Parallel Peptide Synthesizer provides an economic and easy to use parallel synthesis tool to accelerate your chemistry research. Enabling fast lead generation, optimization, process development, combinatorial catalysis etc utilizing a range of PTFE solid phase and glass solution phase reactors.
Can be used for low cost multiple peptide synthesis too!
- Solution phase chemistry and/or solid phase chemistry
- Multiple peptide synthesis
- Scales from 0.5 mL to 50 mL
- Vortex mixing – variable speed
- Heating to +150°C, cooling to -80°C
- Suzuki reactions, amide bond formation, reductive aminations etc etc
- Parallel washing, product retrieval and cleavage
| Activo-PLS Type | Max. Heating | Min. Cooling | No. of temp. zones | No. of reactors places | Reaction volume range | Max Vial/Reactor diameter | Solid or solution phase capable |
| PLS4x6 | Y+150°C | N | 4 | 24 | 0.5mL – 6.0mL | 17.1 mm | Both |
| PLS4x4 | Y+150°C | N | 4 | 16 | 2.0mL – 14.0mL | 27.8 mm | Both |
| PLSHybrid | Y+150°C | N | 4 | 20 – 2 rows of 6, 2 rows of 4 | 0.5mL – 14.0mL | 17.1mm and 27.8mm | Both |
| PLS50 | Y+70°C | N | 4 | 4 | 30mL in a 50mL reactor | n/a | Solution |
| PLS24 | Y+150°C | Y -80°C | 1 | 24 | 0.5mL – 6.0mL | 17.1 mm | Both |
| PLS6 | Y+150°C | Y -80°C | 1 | 6 | 10.0mL – 50mL | 40.5mm | Both |
PLS4x6, PLS4x4 and PLS50 reactor blocks can be interchanged on the same base.
PLS24 and PLS6 reactor blocks can be interchanged on the same base.
PLS4x6
- 4 rows with individual temperature control from room temperature to +150°C
- Synthesis scale from 0.5 mL to 5 mL
PLS4x4
- 4 rows with individual temperature control from room temperature to +150°C
- Synthesis scale up to 20 mL
PLS50
- 4 rows with individual temperature control from room temperature to +150°C
- 4 x 50mL round bottom flasks
PLS24 – cool to -80°C in just 20 mins!!
- Heating and cooling from -80°C to +150°C
- Dry box prevents any ice formation on cooling
- Synthesis scale from 0.5 mL to 5 mL
PLS6
- Heating and cooling from -80°C to +150°C
- Synthesis scale up to 50 mL
Activo-S44 Automated Organic Synthesizer
The S44 Automated Organic Synthesizer is an easy to use and affordable instrument for automated synthesis of organic chemistry.
Key Features
- High quality compounds
- Any scale from 0.05 mmol to 2.0 mmoles
- Easy to use; use prewritten or define own protocols
- Performs wide range of solid phase chemistries
- Reactor cooling to -30°C and heating to +80°C
- Safe to use, instrument is totally enclosed
- Fully automatic with no limit to number of building blocks
- Disposable 10 mL and 50 mL reactors
- Uses commercially available resins and reagents
Ease of Use
- Very easy to use software; import the sequence, fill in quantity and resin and press run
- Software generated worksheet tells the user what to prepare
- Free choice of chemistry, present and future
- Unattended operation for full length of the synthesis
- Disposable reactors and building block containers
- 60 building block containers, no limit to how many can be added
- Enclosed cabinet for safe bench top use
- Easy cleave system direct from the disposable reactor
High Quality Compound
- Inert atmosphere throughout
- Reaction temperature monitoring and logging
- Precise and fast reagent delivery and washing
- Efficient inversion mixing
- Bottom filtration from disposable reactors
- Fresh building blocks in powder
- Pre-activation vessel
- Multi-tasking
Dimensions
Width – 84 cm or 33 inches, depth – 60 cm or 23 inches, height – 70 cm or 28 inches
